Genetic basis for variation of vaccine response: our studies with rubella vaccine
نویسندگان
چکیده
منابع مشابه
Genetic basis for variation of vaccine response: our studies with rubella vaccine.
Congenital rubella syndrome still occurs throughout the world despite an effective vaccine being used in developed countries. Heat and light lability, as well as contraindications in immunocompromised persons, limit the use of the vaccine. An improved, more durable and less reactive rubella vaccine such as a peptide or subunit vaccine would address these unmet needs. We have sought to identify ...
متن کاملReplication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations.
Purported genetic associations found in population studies require validation for confirmation. We previously reported rubella vaccine-induced immune responses and HLA associations in 346 adolescents, age 12-18 years (1st cohort), following two doses of a rubella-containing vaccine. We sought to replicate the associations discovered in that work by verifying these associations in a new cohort o...
متن کاملDifferential immune response to attenuated rubella virus vaccine.
Serum samples collected from 18 volunteers 1, 2, and 3 months after vaccination with Cendehill strain of attenuated rubella virus vaccine were fractionated on a Sephadex G-200 column to test for immunoglobulin M (IgM) antibody. Seventeen of the 18 had demonstrable IgM antibody in serum collected 1 month postvaccination whereas only 5 and 3 had IgM antibody 2 and 3 months, respectively, post-ino...
متن کاملGenetic determinants of hepatitis B vaccine response
Hepatitis B is a major public health problem. Approximately one-third of the world’s population has serological evidence of infection with hepatitis B virus (HBV). 350 million of these are carriers who have chronic HBV infection, and about a million of these carriers die each year from chronic liver disease, including cirrhosis and liver cancer. Fortunately, HBV is a vaccine preventable disease...
متن کاملThe Measles, Mumps, and Rubella (MMR) Vaccine
In 1971 Maurice Hillemanat at the Merck Institute of Therapeutic Research, a pharmaceutical company in West Point, Pennsylvania, created the measles, mumps, and rubella (MMR) vaccine. The vaccine combined three separate vaccines for measles, mumps, and rubella, common and sometimes fatal diseases. Measles causes a red skin rash and severe fevers that can be fatal. Mumps causes fever and swellin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Paediatrics and Child Health
سال: 2009
ISSN: 1751-7222
DOI: 10.1016/j.paed.2009.08.019